Onkure Scientists in lab

John Talley, Ph.D.


Dr. John Talley, the Chief Scientific Advisor for Forward, is one of the world's most successful medicinal chemists, bringing over 30 years of industry experience to the R&D team. He is the inventor of Celebrax (celecoxib), Pfizer's blockbuster product-COX-2 inhibitor, which has generated cumulative sales of over $50 billion for Pfizer. Other drugs including Dynastat (parecoxib) and Bextra were also subsequently invented by him. In addition, Dr. Talley has led the development of the HIV protease inhibitors Agenerase, Lexiva and Prezista. During his career, Dr. John Talley has invented 8 new drugs that have been marketed worldwide, and has several subsequent drugs still in development. Dr. Talley served as the Senior Vice President (SVP) of Ironwood Pharmaceuticals and held key positions at G. D. Searle and Pharmacia. He holds over 215 U.S. granted patents, has published over 50 influential academic dissertations, and was awarded the Excellence in Invention Award by the American Society for Drug Development and Manufacturing in 2002.